1-Chloro-4-isocyanato-2-(trifluoromethyl) benzene → HCID 57974580, compound

Participants

Reaction Steps

Method H3 was used with 4-(4-amino-2-chlorophenoxy)-3-nitropyridin-2-amine (0.40 g, 1.42 mmol) and 4-chloro-3-(trifluoromethyl)phenyl isocyanate (0.32 g, 1.42 mmol) to afford the title compound (0.71 g, 100%). 1H NMR (250 MHz, DMSO-d6) δ 5.86 (d, 1H, J=5.6 Hz), 7.22 (s, 2H), 7.35 (d, 1H, J=8.8 Hz), 7.44 (dd, 1H, Ja=8.8 Hz, Jb=2.4 Hz), 7.60-7.69 (m, 2H), 7.87 (d, 1H, J=2.4 Hz), 7.99 (d, 1H, J=5.7 Hz), 8.10 (d, 1H, J=2.1 Hz), 9.17 (s, 1H), 9.29 (s, 1H). m/z 502.2 [(M+H)+ calcd. for C19H12Cl2F3N5O4 501.0].

Provenance & Evidence