1-Chloro-4-isocyanato-2-(trifluoromethyl) benzene → HCID 44186092, compound

Participants

Reaction Steps

Method H3 was used with 4-(4-amino-2-fluorophenoxy)-3-nitropyridin-2-amine (0.25 g, 0.946 mmol) and 4-chloro-3-(trifluoromethyl)phenyl isocyanate (0.21 g, 0.946 mmol) to afford the title compound (0.19 g, 42%). 1H NMR (250 MHz, 6, ppm, DMSO-d6): 5.98 (dd, 1H, Ja=5.7 Hz, Jb=1.0 Hz), 7.21 (s, 2H), 7.26 (dd, 1H, Ja=9.1 Hz, Jb=2.3 Hz), 7.34 (t, 1H, J=8.8 Hz), 7.60-7.73 (m, 3H), 8.01 (d, 1H, J=5.7 Hz), 8.10 (d, 1H, J=2.1 Hz), 9.19 (s, 1H), 9.27 (s, 1H). m/z 486.1 [(M+H)+ calcd. for C19H12ClF4N5O4 485.1].

Provenance & Evidence