1-Chloro-4-isocyanato-2-(trifluoromethyl) benzene → HCID 57974612, compound

Participants

Reaction Steps

Method H3 was used with 4-(4-amino-2-methylphenoxy)-3-nitropyridin-2-amine (0.22 g, 0.991 mmol) and 4-chloro-3-(trifluoromethyl)phenyl isocyanate (0.16 g, 0.709 mmol) to afford the title compound (0.49 g, 100%). 1H NMR (250 MHz, 6, ppm, DMSO-d6): 2.10 (s, 3H), 5.81 (d, 1H, J=5.7 Hz), 7.08 (d, 1H, J=8.7 Hz), 7.14 (s, 2H), 7.37 (dd, 1H, Ja=8.8 Hz, Jb=2.6 Hz), 7.49 (d, 1H, J=2.4 Hz), 7.58-7.66 (m, 2H), 7.96 (d, 1H, J=5.7 Hz), 8.12 (d, 1H, J=2.1 Hz), 8.89 (s, 1H), 9.16 (s, 1H). m/z 482.1 [(M+H)+ calcd. for C20H15ClF3N5O4 481.1].

Provenance & Evidence