HCID 178430168, compound → HCID 178430190, compound

HRID 1864702Notes

Reaction equation

HRID 1864702 reaction equation
[Si]([O:8][C@@H:9]1[C@H:16]2[N:12](/[C:13](=[N:21]/[C:22]3[CH:29]=[CH:28][C:25]([C:26]#[N:27])=[C:24]([Cl:30])[C:23]=3[CH3:31])/[O:14][C@H:15]2[C:17]([F:20])([F:19])[F:18])[CH2:11][CH2:10]1)(C(C)(C)C)(C)C.O[C@H]1[C@@H]2N(/C(=N/C3C=CC(C#N)=C(Cl)C=3C)/OC2)CC1>>[OH:8][C@@H:9]1[C@@H:16]2[N:12](/[C:13](=[N:21]/[C:22]3[CH:29]=[CH:28][C:25]([C:26]#[N:27])=[C:24]([Cl:30])[C:23]=3[CH3:31])/[O:14][C@H:15]2[C:17]([F:18])([F:20])[F:19])[CH2:11][CH2:10]1

Participants

3

Reactant 2

HCID 178430168HCID 178430168, compoundHCID 178430193HCID 178430193, compound

Product 1

HCID 178430190HCID 178430190, compound

Procedure

The title compound was prepared from compound 5F following the procedure found in Example 1 for the preparation of compound 1J. LCMS: m/z 360 [M+H]+. The double bond geometry was confirmed via X-ray analysis.

Sources & evidence

ORD record
ord-d3d365d5b57b4acd8af0ac041bb4a85d
Source dataset
uspto-grants-2009_12
Patent number
US07625923B2

Reaction notes

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