反应详情

Ethanol (20 mL) is added to 4-[1-(3-Nitro-benzyl)-1H-imidazol-2-yl]-pyridine (730 mg, 2.6 mmol) and 10% palladium on charcoal (100 mg) under an atmosphere of argon. The atmosphere is purged 3 times with H2 on a Parr shaker type hydrogenation apparatus, and the mixture is shaken for 4 h at 50 psi H2. The mixture is filtered through celite, and the filter pad is washed with DCM and MeOH (1:1). The solution was concentrated under reduced pressure to afford 3-(2-Pyridin-4-yl-imidazol-1-ylmethyl)-phenylamine as an off-white solid.

1. customThe atmosphere is purged 3 times with H2 on a Parr shaker type hydrogenation apparatus
2. filtrationThe mixture is filtered through celite
3. washthe filter pad is washed with DCM and MeOH (1:1)
4. concentrationThe solution was concentrated under reduced pressure