反应详情

温度

50 °C

A mixture of 4.48 g (5.71 mmol) of ethyl 4-{4-[benzyl((2S)-3-{4-(benzyloxy)-3-[(methylsulfonyl)-amino]phenoxy}-2-hydroxypropyl)amino]cyclohexyl}benzoate and 38 ml of a 1N aqueous sodium hydroxide solution in 114 ml of ethanol is heated at 50° C. overnight. The solvents are evaporated, the medium is taken up in water and a 1N hydrochloric acid solution is gently added to pH=1. The medium is filtered and dried under vacuum. The title compound (4.05 g, 94%) is thus obtained in the form of a white solid (melting point=160° C.).

1. customThe solvents are evaporated
2. additiona 1N hydrochloric acid solution is gently added to pH=1
3. filtrationThe medium is filtered
4. customdried under vacuum