1-Acetylpiperazine → HCID 69021862, compound

Participants

Reaction Steps

To a solution of 57 mg (0.137 mmol) 3-6 in 1.0 mL of anhydrous DCE under Ar was added 26.3 mg (0.206 mmol) 1-acetylpiperazine followed by 58.1 mg (0.274 mmol) sodium triacetoxyborohydride. The mixture stirred overnight before quenching with saturated aqueous NaHCO3 solution and adding a small amount of DCM. The aqueous phase was re-extracted with DCM and the organic phases were loaded directly onto silica gel for flash chromatography using a mixture of hexanes, EtOAc, and 20:1:1 EtOH—NH4OH—H2O to give 3-7 as a white solid.

Provenance & Evidence