HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium formate → HCID 68749290, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium formate | HCID 2723923 | — |
| Reactant | 2-(Trimethylsilyl)ethyl 4-oxopiperidine-1-carboxylate | HCID 22265950 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 68749290 | HCID 68749290 | 40.1% |
Reaction Steps
A slurry of 10% palladium on carbon (200 mg) in water was added to 4-oxo-piperidine-1-carboxylic acid-2-trimethylsilanyl-ethyl ester (2.42 g, 10 mmol) in 100 mL of methanol. Ammonium formate (6.0 g, 95 mmol) in water was added dropwise, and the mixture stirred vigorously overnight. The mixture was filtered and the filtrate concentrated in vacuo to leave the crude product. Chromatography (elution with methanol-dichloromethane) provided 0.98 g of product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07625889B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-e09efe30857045cbbddb93b978dbd682 |
| Source note | uspto-grants-2009_12 |