HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1864807Generated: October 25, 2026
Benzylamine → 3-Benzyl-3-azabicyclo(3.1.0)hexane-2,4-dione
https://huagongshe.com/reaction/1864807
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | (1r,5s)-3-Oxabicyclo[3.1.0]hexane-2,4-dione | HCID 12688062 | — |
| Product | 3-Benzyl-3-azabicyclo(3.1.0)hexane-2,4-dione | HCID 2764586 | — |
Reaction Steps
Benzylamine (8.8 mmol, 9.97 ml) was added dropwise to ice cooled cis-1,2-cyclopropanedicarboxylic acid anhydride (8.8 mmol, 0.99 g). After that the mixture was heated to 180° C. for 2 h on an oil bath. After cooling to r.t. the resulting solid oil was recrystallised from isopropanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07625939B2 |
|---|
| Source dataset | uspto-grants-2009_12 |
|---|
| ORD ID | ord-e2274b205ecf4871a979796d24b0ee64 |
|---|
| Source note | uspto-grants-2009_12 |
|---|
