2-Bromo-5-chloropyrimidine → trans-3-{4-[(5-Chloro-pyrimidin-2-yl)-methyl-amino]-cyclohexyl}-prop-2-yn-1-ol

HRID 186485Notes

Reaction equation

HRID 186485 reaction equation
[Br:13][c:14]1[n:15][cH:16][c:17]([Cl:20])[cH:18][n:19]1.[CH3:1][NH:2][CH:3]1[CH2:4][CH2:5][CH:6]([C:9]#[C:10][CH2:11][OH:12])[CH2:7][CH2:8]1>>[CH3:1][N:2]([CH:3]1[CH2:4][CH2:5][CH:6]([C:9]#[C:10][CH2:11][OH:12])[CH2:7][CH2:8]1)[c:14]1[n:15][cH:16][c:17]([Cl:20])[cH:18][n:19]1

Participants

3

Reactant 2

HCID 222362732-Bromo-5-chloropyrimidineHCID 22236325trans-3-(4-Methylamino-cyclohexyl)-prop-2-yn-1-ol

Product 1

HCID 22236313trans-3-{4-[(5-Chloro-pyrimidin-2-yl)-methyl-amino]-cyclohexyl}-prop-2-yn-1-ol

Sources & evidence

ORD record
ord-51912f2c5d084c7fa6b59bce0e6d1cbb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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