1-Aminocyclohexanecarboxylic acid → Methyl 1-aminocyclohexane-1-carboxylate hydrochloride

HRID 1864883Notes

Reaction equation

HRID 1864883 reaction equation
F[C:2]1C=C([C@H]2N(CC(OCC)=O)C(=O)C3(CCCC3)NC2)C=C(F)C=1.[ClH:26].[NH2:27][C:28]1([C:33]([O:35][CH3:36])=[O:34])[CH2:32][CH2:31][CH2:30][CH2:29]1.NC1(C(O)=O)CCCCC1>>[ClH:26].[NH2:27][C:28]1([C:33]([O:35][CH3:36])=[O:34])[CH2:32][CH2:31][CH2:30][CH2:29][CH2:2]1

Participants

4

Reactant 3

HCID 13661-Aminocyclohexanecarboxylic acidHCID 11513856Methyl 1-amino-1-cyclopentanecarboxylate, HClHCID 70805595HCID 70805595, compound

Product 1

HCID 22645079Methyl 1-aminocyclohexane-1-carboxylate hydrochloride

Procedure

Essentially following the procedures described in Intermediate 25 for methyl 1-aminocyclopentanecarboxylate hydrochloride, but using 1-aminocyclohexanecarboxylic acid in place of 1-aminocyclopentanecarboxylic acid, the title compound was obtained. MS: m/z=158 (M+1).

Sources & evidence

ORD record
ord-e454492519874530ab5c9f1bb27f1961
Source dataset
uspto-grants-2009_12
Patent number
US07625901B2

Reaction notes

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