Tetraethyltin → HCID 86625746, compound

Participants

Reaction Steps

A solution of benzyl (3,5-dichloro-2-oxo-6-phenylpyrazin-1 (2H)-yl)acetate [Parlow et al. (2003) J. Med. Chem. 46, 4050-4062] (1.05 g, 2.70 mmol), tetraethyltin (0.641 mL, 3.24 mmol), and tetrakis(triphenylphosphine)palladium (31.0 mg, 0.027 mmol) in toluene (15 mL) was heated at reflux for 5.5 h. The solution was concentrated in vacuo and the crude product purified by silica gel chromatography, eluting with a gradient of CH2Cl2:EtOAc-100:0 to 90:10 to give the title compound. MS: m/z=383 (M+1).

Provenance & Evidence