HCID 54495182, compound → HCID 178523783, compound

HRID 1864965Notes

Reaction equation

[F:1][C:2]([F:28])([F:27])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:10]([C:15]([NH:17][CH:18]3[CH2:23][CH2:22][CH:21]([C:24]([OH:26])=[O:25])[CH2:20][CH2:19]3)=[O:16])=[CH:11][CH:12]=[CH:13][CH:14]=2)=[CH:5][CH:4]=1.[F:29][C:30]([F:52])([F:51])[CH2:31][NH:32][C:33]([C:35]1([CH2:48][CH2:49]O)[C:47]2[CH:46]=[CH:45][CH:44]=[CH:43][C:42]=2[C:41]2[C:36]1=[CH:37][CH:38]=[CH:39][CH:40]=2)=[O:34]>>[F:29][C:30]([F:51])([F:52])[CH2:31][NH:32][C:33]([C:35]1([CH2:48][CH2:49][O:25][C:24]([C@H:21]2[CH2:20][CH2:19][C@H:18]([NH:17][C:15]([C:10]3[C:9]([C:6]4[CH:7]=[CH:8][C:3]([C:2]([F:27])([F:28])[F:1])=[CH:4][CH:5]=4)=[CH:14][CH:13]=[CH:12][CH:11]=3)=[O:16])[CH2:23][CH2:22]2)=[O:26])[C:47]2[CH:46]=[CH:45][CH:44]=[CH:43][C:42]=2[C:41]2[C:36]1=[CH:37][CH:38]=[CH:39][CH:40]=2)=[O:34]

Participants

Reactant 2

HCID 54495182HCID 54495182, compound

HCID 57683266HCID 57683266, compound

Product 1

HCID 178523783HCID 178523783, compoundYield 51.7%

Procedure

The 4-[(4′-trifluoromethylbiphenyl-2-carbonyl)amino]cyclohexanecarboxylic acid (0.570 g) obtained in Example 7a) and 9-(2-hydroxyethyl)-9H-fluoren-9-carboxylic acid (2,2,2-trifluoroethyl)amide (0.500 g) obtained in Example 6d) were treated in a similar manner to Example 1g) to give the title compound (0.534 g) as a colorless solid (see Table 57).

Sources & evidence

ORD record: ord-065f7e429d50470ea1da023b71427698
Source dataset: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07625948B2

Reaction notes

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