Diethyl 2-(hydroxymethyl)-2-phenylmalonate → 2-(2-{3-Ethoxycarbonyl-4-[(4'-trifluoromethylbiphenyl-2-carbonyl)amino]phenyl}acetoxymethyl)-2-phenylmalonic acid diethyl ester

Participants

Reaction Steps

The 3-ethoxycarbonyl-4-[(4′-trifluoromethylbiphenyl-2-carbonyl)amino]phenylacetic acid (0.532 g) obtained in Example 9-4e) and the 2-hydroxymethyl-2-phenylmalonic acid diethyl ester (1.04 g) obtained in Example 1-2a) were treated in a similar manner to Example 1g) to give the title compound (0.524 g) (see Table 59).

Provenance & Evidence