HCID 69019986, compound → HCID 69020066, compound

Participants

Reaction Steps

Prepare a solution of 4-cyano-3-(2′-cyano-biphenyl-4-yl)-5-ethyl-1-methyl-1H-pyrrole-2 carboxylic acid amide (167 mg, 0.47 mmol, prepared in example Am-3) in 2.5 mL of dry dimethoxymethyl-dimethyl-amine and heat to reflux under nitrogen. After 1 hour allow 1 mL of solvent to distill out of the reaction, then cool the mixture to room temperature. Dilute the slurry with 10 mL of hexanes, filter off the resulting product and wash with 5 mL hexanes. Vacuum-dry the solid overnight to give the title compound (183 mg, 95%). MS(ES+, m/e)=410 (M++1).

Provenance & Evidence