Boron tribromide → HCID 69022979, compound

Participants

Reaction Steps

Add boron tribromide (1.60 g, 6.39 mmol) to 4-cyano-3-(2′-methoxy-biphenyl-4-yl)-1-methyl-1H-pyrrole-2-carboxylic acid ethyl ester (2.10 g, 5.81 mmol, prepared in example E-17) in methylene chloride at 0° C. with stirring. The reaction is gradually allowed to warm to ambient temperature. After 18 hours, pour the reaction mixture into ice-water and extract with methylene chloride. Combine the organic extracts, wash with water and brine, dry over anhydrous magnesium sulfate, filter and concentrate under reduced pressure. Purify the residue by flash chromatography eluting with acetonitrile:methylene chloride to provide the title compound. Mass spectrum (m/e): 345.1 (M−1).

Provenance & Evidence