7-Bromobenzo[b]thiophene → HCID 69020247, compound

HRID 1865087Notes

Reaction equation

HRID 1865087 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[N:7]([CH3:29])[C:8](CC)=[C:9]([C:25]#[N:26])[C:10]=1[C:11]1[CH:16]=[CH:15][C:14](OS(C(F)(F)F)(=O)=O)=[CH:13][CH:12]=1)=[O:5])[CH3:2].Br[C:31]1[C:36]2[S:37][CH:38]=[CH:39][C:35]=2[CH:34]=[CH:33][CH:32]=1>>[CH2:1]([O:3][C:4]([C:6]1[N:7]([CH3:29])[CH:8]=[C:9]([C:25]#[N:26])[C:10]=1[C:11]1[CH:12]=[CH:13][C:14]([C:31]2[C:36]3[S:37][CH:38]=[CH:39][C:35]=3[CH:34]=[CH:33][CH:32]=2)=[CH:15][CH:16]=1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 120455387-Bromobenzo[b]thiopheneHCID 57974728HCID 57974728, compound

Product 1

HCID 69020247HCID 69020247, compound

Procedure

Prepare the title compound in the manner analogous to the procedure set fourth in example E-222 using 4-cyano-5-ethyl-1-methyl-3-(4-trifluoromethanesulfonyloxyphenyl)-1H-pyrrole-2-carboxylic acid ethyl ester (prepared in example E-97a or 97b) and 7-bromo-benzo(b)thiophene. Purify the material by silica gel chromatography (Chromatotron™ eluting with methylene chloride/ethyl acetate 4:1 to provide the title compound a white solid. Mass spectrum (m/e): 413.2 (M*−1).

Workup

  1. customPurify the material by silica gel chromatography (Chromatotron™
  2. washeluting with methylene chloride/ethyl acetate 4:1

Sources & evidence

ORD record
ord-8d4022337c4a4b51abd865422101a0d6
Source dataset
uspto-grants-2009_12
Patent number
US07625932B2

Reaction notes

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