HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Fluoronitrobenzene → 1-Fluoro-2-(4-nitrophenoxy)benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Fluoronitrobenzene | HCID 9590 | — |
| Reactant | 2-Fluorophenol | HCID 9707 | — |
| Reactant | Ethanamine, N,N-diethyl-2-(2-(3-methyl-5-isoxazolyl)phenoxy)-, monohydrochloride | HCID 40904 | — |
| Product | 1-Fluoro-2-(4-nitrophenoxy)benzene | HCID 57974999 | — |
Reaction Steps
Prepare the title compound in the manner analogous to the procedure set fourth in example E-221 using 4-fluoro-nitrobenzene and 2-fluorophenol (heat 2 hours at 60° C.). Purify the material by silica gel chromatography (Prep. 2000) eluting with methylene chloride/hexane 1:1 to provide the title compound as a yellow solid. Mass spectrum (m/e): 233.1 (M*). (Bruker 300) 1H NMR (CDCl3) 8.17-8.22 (2H, d), 7.14-7.28 (4H, m), 6.96-700 (2H, d).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07625932B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-152aecbe351b4e608352a6452323b057 |
| Source note | uspto-grants-2009_12 |