Cesium carbonate → 4-cyano-5-ethyl-1-methyl-3-(4-pyrrolidin-1-yl-phenyl)-1H-pyrrole-2-carboxylic acid ethyl ester

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Reaction Conditions

Reaction Steps

Add 4-cyano-5-ethyl-1-methyl-3-(4-trifluoromethanesulfonyloxy-phenyl)-1H-pyrrole-2-carboxylic acid ethyl ester (0.3 g, 0.697 mmol, 1.0 eq, prepared in example E-97b or 97b), pyrrolidine (0.069 ml, 0.836 mmol, 1.2 eq), Pd(OAc)2 (4.69 mg, 0.0209 mmol, 0.03 eq), BINAP (19.53 mg, 0.0314 mmol, 0.045 eq) and cesium carbonate (0.318 g, 0.976 mmol, 1.4 eq) in toluene and heat at 100° C. with stirring. After 4 hours, stop reaction and let it cool down to room temperature. Partition the mixture between water and ethyl acetate. Separate the aqueous layer and extract it with ethyl acetate three times. Combine organic solution, dry over anhydrous sodium sulfate, filter, and concentrate under reduced pressure. Purify the crude with flash chromatography eluting with 1:3 EtOAc/Hexane to provide 0.176 g (72%) of desired product as light yellow solid. Mass spectrum (m/e) 352.3 (M+1)

Provenance & Evidence