N-Iodosuccinamide → HCID 69020058, compound

HRID 1865128Notes

Reaction equation

[C:1]([C:3]1[C:4]([C:13]2[CH:18]=[CH:17][C:16]([C:19]3[S:20][CH:21]=[CH:22][C:23]=3[S:24][CH3:25])=[CH:15][CH:14]=2)=[C:5]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[NH:6][CH:7]=1)#[N:2].[I:26]NC(=O)CCC(N)=O>>[C:1]([C:3]1[C:4]([C:13]2[CH:14]=[CH:15][C:16]([C:19]3[S:20][CH:21]=[CH:22][C:23]=3[S:24][CH3:25])=[CH:17][CH:18]=2)=[C:5]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[NH:6][C:7]=1[I:26])#[N:2]

Participants

Reactant 2

HCID 21864724N-Iodosuccinamide

HCID 69019970HCID 69019970, compound

Product 1

HCID 69020058HCID 69020058, compound

Procedure

In a manner analogous to the procedure set forth in example A-237, the title compound is prepared by iodinating ethyl 4-cyano-3-[4-(3 methylthio(2-thienyl))phenyl]pyrrole-2-carboxylate, prepared directly above, with N-iodo-succinamide.

Sources & evidence

ORD record: ord-6b955f2c93654de3b65820729382079c
Source dataset: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07625932B2

Reaction notes

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