Hydrochloric Acid → HCID 69023914, compound

Participants

Reaction Steps

Dissolve the 5-cyano-4-(2′-cyano-biphenyl-4-yl)-2-methyl-2H-pyrazole-3-carboxylic acid ethyl ester (37 mg, 0.10 mmol, prepared in example Pz-2) in 2 mL of EtOH, add 1 mL of 2N aqueous NaOH and heat to reflux. After 20 minutes cool the reaction mixture in an ice-bath and add 2 mL of 1N aqueous HCl. Stir 10 minutes and filter, rinsing with 1 mL of EtOH followed by 2 mL of water. Vacuum-dry at 50° C. overnight to give the title compound. Yield=7.0 mg (21%). MS(ES−, m/e)=283 (M+−COOH).

Provenance & Evidence