反应详情

A mixture of 20 g of dry sucralose-6-acetate obtained from Example 5 and 70 ml of methanol was heated to from 40° C. to 50° C. When the reacting mixture became a clear solution, a small quantity of a 30% sodium methylate solution was added. After the mixture was stirred for 2 hours, methanol was removed under reduced pressure. The resultant mixture was diluted to a 30% mixture by adding a certain quantity of water, which was decolored and then filtered. The filtrate thus obtained was concentrated to a 65% solution, which was cooled to form crystallized sucralose. The obtained crystal was filtered and dried to give sucralose with a yield of over 95% and purity of over 98.0%.

1. temperaturewas heated to from 40° C. to 50° C
2. custommethanol was removed under reduced pressure
3. additionThe resultant mixture was diluted to a 30% mixture
4. additionby adding a certain quantity of water, which
5. filtrationfiltered
6. customThe filtrate thus obtained
7. concentrationwas concentrated to a 65% solution, which
8. temperaturewas cooled
9. customto form
10. customcrystallized sucralose
11. filtrationThe obtained crystal was filtered
12. customdried