Citric Acid → HCID 68698989, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 4-[(3R)-3-(1-tert.-butoxycarbonylaminocyclopropyl)-pyrrolidin-1-yl]-2-fluoro-3-methoxybenzoic acid (3.61 g) was dissolved in 28 mL of ethanol, 1N aqueous sodium hydroxide solution (34.5 mL) was added to the solution, and the mixture was heated to 50° C. with stirring. After completion of the reaction, 10% aqueous citric acid solution was added to the mixture followed by extraction with chloroform. An organic layer was dried with anhydrous sodium sulfate and filtered, and then the solvent was distilled away. The title compound was obtained as residual crystals (4.45 g). The crystals were used in the next step without purification.

Provenance & Evidence