1,4-Dioxane hydrochloride → HCID 69018892, compound

HRID 1865193Notes

Reaction equation

HRID 1865193 reaction equation
C([O:3][C:4](=O)[CH2:5][C:6]1[C:11]([NH2:12])=[CH:10][CH:9]=[C:8]([O:13][CH:14]2[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][O:22][CH3:23])[CH2:16][CH2:15]2)[N:7]=1)C.[ClH:25].O1CCOCC1>C(O)C>[ClH:25].[CH3:23][O:22][CH2:21][CH2:20][N:17]1[CH2:18][CH2:19][CH:14]([O:13][C:8]2[N:7]=[C:6]3[CH2:5][C:4](=[O:3])[NH:12][C:11]3=[CH:10][CH:9]=2)[CH2:15][CH2:16]1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 57976116HCID 57976116, compound

Product 1

HCID 69018892HCID 69018892, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a mixture of 5 (0.483 mmol) in ethanol (5 mL) was added 4M HCl/Dioxane (15 mL). The solution was agitated at room temperature for 18 hours. All components in reaction are extremely polar and elute with solvent front. By LCMS, 6 was the major observed ion. The crude material was concentrated and taken directly on to the next step without purification.

Workup

  1. customAll components in reaction
  2. washelute with solvent front
  3. concentrationThe crude material was concentrated
  4. customtaken directly on to the next step without purification

Sources & evidence

ORD record
ord-4c69dd3aedb44d9bb075baf7c117dcfe
Source dataset
uspto-grants-2009_12
Patent number
US07626031B2

Reaction notes

Loading…