HCID 57976104, compound → HCID 57976099, compound

Participants

Reaction Steps

2-{2-[1-(2-Methoxy-ethyl)-piperidin-4-ylamino]-5-nitro-pyrimidin-4-yl}-malonic acid tert-butyl ester ethyl ester (5, 733 mgs, 1.6 mmol) was dissolved in a mixture of MeOH (15 mls) and EtOAc (5 mls) to which was added 10% Pd/C (137 mgs). The reaction mixture was stirred under an atmosphere of H2 at room temperature and pressure for 2 hrs, filtered through Celite with thorough washing with MeOH and the filtrate concentrated in vacuo to give 2-{5-amino-2-[1-(2-methoxy-ethyl)-piperidin-4-ylamino]-pyrimidin-4-yl}-malonic acid tert-butyl ester ethyl ester (6, 677 mgs, 99%) which was used in the next reaction without further purification. LC/MS Calcd for [M+H]+ 438, found 438.

Provenance & Evidence