HCID 57976099, compound → HCID 57976122, compound

Participants

Reaction Steps

2-{5-Amino-2-[1-(2-methoxy-ethyl)-piperidin-4-ylamino]-pyrimidin-4-yl}-malonic acid tert-butyl ester ethyl ester (6, 658 mgs, 1.5 mmol) was dissolved in AcOH (8.0 mls) and stirred at room temperature for approximately 4 hrs. The reaction mixture was concentrated in vacuo and dried under high vacuum overnight to give 2-[1-(2-methoxy-ethyl)-piperidin-4-ylamino]-6-oxo-6,7-dihydro-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid tert-butyl ester (7, 785 mgs, ˜100%) as a mixture of acetate salts which was used as is in the next reaction without further purification. LC/MS Calcd for [M+H]+ 392, found 392.

Provenance & Evidence