HCID 57976102, compound → HCID 178495809, compound

Participants

Reaction Steps

A mixture of crude 2-[1-(2-methoxy-ethyl)-piperidin-4-ylamino]-5,7-dihydro-pyrrolo[3,2-d]pyrimidin-6-one, TFA salts (8, 519 mgs, 0.71 mmol) and (1H-benzoimidazol-2-yl)-(3-chloro-phenyl)-methanone (9, 192 mgs, 0.75 mmol) was dissolved in EtOH saturated with ammonia (8.0 mls) and the mixture stirred at 90 C in a sealed reaction vessel overnight. The reaction mixture was concentrated in vacuo and purified by preparative HPLC to give 7-[(1H-Benzoimidazol-2-yl)-(3-chloro-phenyl)-methylene]-2-[1-(2-methoxy-ethyl)-piperidin-4-ylamino]-5,7-dihydro-pyrrolo[3,2-d]pyrimidin-6-one (10). LC/MS Calcd for [M+H]+ 530, found 530.

Provenance & Evidence