HCID 22278881, compound → HCID 22278913, compound

HRID 1865268Notes

Reaction equation

HRID 1865268 reaction equation
[CH3:1][NH:2][CH:3]1[CH:8]([CH3:9])[CH2:7][N:6](C(OCC)=O)[CH2:5][CH:4]1[CH3:15]>[OH-].[Na+].C(O)C>[CH3:1][NH:2][CH:3]1[CH:8]([CH3:9])[CH2:7][NH:6][CH2:5][CH:4]1[CH3:15]

Participants

4

Reactant 1

HCID 22278881HCID 22278881, compound

Product 1

HCID 22278913HCID 22278913, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

Mixtures A+B of 4-methylamino-1-carbethoxy-3,5-dimethylpiperidine (1.3 g, 0.6 mmol) was stirred in a mixture of 10% NaOH solution (20 ml) and ethyl alcohol (10 ml) at 100° C. for 120 hr, cooled, extracted with ethyl acetate, dried (Na2SO4) and concentrated to afford a Mixtures A+B of 4-methylamino-3,5-dimethylpiperidine. Yield 0.61 g (70%), C8H18N2, m/z 143 (M+1).

Workup

  1. temperaturecooled
  2. extractionextracted with ethyl acetate
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-848229894774417883ac80fed6000919
Source dataset
uspto-grants-2009_12
Patent number
US07626032B2

Reaction notes

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