HCID 22278901, Verbindung → HCID 22278857, Verbindung

HRID 1865274Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1865274
C([N:8]1[CH2:13][CH:12]([CH3:14])[CH:11]([N:15]([CH3:17])[CH3:16])[CH:10]([CH3:18])[CH2:9]1)C1C=CC=CC=1>CO.[H][H].[OH-].[OH-].[Pd+2]>[CH3:16][N:15]([CH3:17])[CH:11]1[CH:10]([CH3:18])[CH2:9][NH:8][CH2:13][CH:12]1[CH3:14]

Komponenten

5

Edukt 1

HCID 22278901HCID 22278901, Verbindung

Produkt 1

HCID 22278857HCID 22278857, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 9942167Palladium hydroxideKatalysatorHCID 887MethanolLösungsmittelHCID 178418361HCID 178418361, VerbindungLösungsmittel

Versuchsvorschrift

A mixture of 20% Pd(OH)2 on carbon (0.5 g) and Mixtures A+B of 1-benzyl-4-dimethylamino-3,5-dimethylpiperidine (2.7 g, 10.1 mmol) in methanol (50 ml) was stirred in hydrogen atmosphere (1 atm.) at 60° C. for 48 hr. The catalyst was filtered off, washed with methanol and filtrate was concentrated to dryness to afford Mixtures A+B of 4-dimethylamino-3,5-dimethylpiperidine. Yield 0.9 g (52.6%), C9H20N2, m/z 157 (M+1).

Aufarbeitung

  1. filtrationThe catalyst was filtered off
  2. washwashed with methanol and filtrate
  3. concentrationwas concentrated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-1b8361ac50af4139bc8d050aa27054d8
Quelldatensatz
uspto-grants-2009_12
Patentnummer
US07626032B2

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