HCID 10171448, compound → HCID 10307880, compound

HRID 1865276Notes

Reaction equation

HRID 1865276 reaction equation
[NH2:1][CH:2]1[CH:7]([CH2:8][CH3:9])[CH2:6][N:5](CC2C=CC=CC=2)[CH2:4][CH:3]1[CH2:17][CH3:18]>CO.[H][H].[Pd]>[NH2:1][CH:2]1[CH:7]([CH2:8][CH3:9])[CH2:6][NH:5][CH2:4][CH:3]1[CH2:17][CH3:18]

Participants

5

Reactant 1

HCID 10171448HCID 10171448, compound

Product 1

HCID 10307880HCID 10307880, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 178418361HCID 178418361, compoundSolvent

Procedure

A mixture of 5% Pd on carbon (0.5 g) and 4-amino-1-benzyl-3,5-diethylpiperidine (3.4 g, 13.82 mmol) in methanol (25 ml) was stirred in hydrogen atmosphere (3 atm.) at 60° C. for 6 hr. The catalyst was filtered off, washed with methanol and filtrate was concentrated to dryness to afford 4-amino-3,5-diethylpiperidine as an oil. Yield 1.4 g (64.5%), C9H20N2, m/z 157 (M+1).

Workup

  1. filtrationThe catalyst was filtered off
  2. washwashed with methanol and filtrate
  3. concentrationwas concentrated to dryness

Sources & evidence

ORD record
ord-27f64ca070c9493e8e16addf06cddb65
Source dataset
uspto-grants-2009_12
Patent number
US07626032B2

Reaction notes

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