HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Dimethylsulfamoyl)benzoic acid → (4,6-Dimethyl-pyrimidin-5-yl)-(5-{2-[4-(3-fluoro-phenyl)-1-(1-trifluoromethyl-cyclopropanecarbonyl)-piperidin-4-yl]-ethyl}-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Dimethylsulfamoyl)benzoic acid | HCID 14572 | — |
| Reactant | 3-Hydroxy-2,2-dimethylpropionic acid | HCID 78548 | — |
| Reactant | 1-Methylcyclopropanecarboxylic acid | HCID 81326 | — |
| Reactant | 3-Sulfamoylbenzoic acid | HCID 229352 | — |
| Reactant | 4-(Methylsulfonamido)benzoic acid | HCID 250653 | — |
| Reactant | 3-(Methylsulfamoyl)benzoic acid | HCID 252654 | — |
| Reactant | 4-(Methylsulfamoyl)benzoic acid | HCID 506056 | — |
| Reactant | 1-(Trifluoromethyl)cyclopropane-1-carboxylic acid | HCID 2778306 | — |
| Reactant | 3-(N,N-dimethylsulfamoyl)benzoic acid | HCID 4985762 | — |
| Reactant | (4,6-Dimethyl-pyrimidin-5-yl)-(5-{2-[4-(3-fluoro-phenyl)-piperidin-4-yl]-ethyl}-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-methanone | HCID 68576683 | — |
| Product | (4,6-Dimethyl-pyrimidin-5-yl)-(5-{2-[4-(3-fluoro-phenyl)-1-(1-trifluoromethyl-cyclopropanecarbonyl)-piperidin-4-yl]-ethyl}-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-methanone | HCID 24937670 | — |
Reaction Steps
The following were prepared analogously from (4,6-dimethyl-pyrimidin-5-yl)-(5-{2-[4-(3-fluoro-phenyl)-piperidin-4-yl]-ethyl}-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-methanone using the carboxylic acid in parenthesis in place of 1-trifluoromethylcyclopropanecarboxylic acid: I-42 (1-methyl-cyclopropanecarboxylic acid), I-15 (4-methylsulfamoyl-benzoic acid), I-16 (4-dimethylsulfamoyl-benzoic acid), I-17 (3-sulfamoyl-benzoic acid), I-18 (3-methylsulfamoyl-benzoic acid), I-19 (3-dimethylsulfamoyl-benzoic acid), I-21 (4-methanesulfonylamino-benzoic acid) and I-44 (2,2-dimethyl-3-hydroxy-propionic acid).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07625905B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-13017b2e51c4422bafd3698600574e1f |
| Source note | uspto-grants-2009_12 |