Acetic Anhydride → HCID 68575922, compound

HRID 1865295Notes

Reaction equation

HRID 1865295 reaction equation
[CH3:1][C:2]1[C:7]([C:8]([N:10]2[CH2:17][CH:16]3[CH:12]([CH2:13][N:14]([CH2:18][CH2:19][C:20]4([C:25]5[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=5)[CH2:24][CH2:23][NH:22][CH2:21]4)[CH2:15]3)[CH2:11]2)=[O:9])=[C:6]([CH3:31])[N:5]=[CH:4][N:3]=1.[C:32](OC(=O)C)(=[O:34])[CH3:33].C1(C(Cl)=O)CCCC1.C1(CC(Cl)=O)CCCC1.C(Cl)(=O)C(C)(C)C>>[CH3:31][C:6]1[C:7]([C:8]([N:10]2[CH2:17][CH:16]3[CH2:15][N:14]([CH2:18][CH2:19][C:20]4([C:25]5[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=5)[CH2:24][CH2:23][N:22]([C:32](=[O:34])[CH3:33])[CH2:21]4)[CH2:13][CH:12]3[CH2:11]2)=[O:9])=[C:2]([CH3:1])[N:3]=[CH:4][N:5]=1

Participants

6

Reactant 5

HCID 7918Acetic AnhydrideHCID 62493Pivaloyl chlorideHCID 78284Cyclopentanecarbonyl chlorideHCID 3485182Cyclopentylacetyl chlorideHCID 68576325HCID 68576325, compound

Product 1

HCID 68575922HCID 68575922, compound

Procedure

The following were prepared analogously from (4,6-dimethyl-pyrimidin-5-yl)-{5-[2-(3-phenyl-pyrrolidin-3-yl)-ethyl]-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl}-methanone using the acid chloride in parenthesis in place of acetic anhydride in the final step: III-1 (cyclopentanecarbonyl chloride), III-2 (cyclopentyl-acetyl chloride) and III-4 (pivaloyl chloride).

Sources & evidence

ORD record
ord-a412c00f8766406abba7c68486b4368c
Source dataset
uspto-grants-2009_12
Patent number
US07625905B2

Reaction notes

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