HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → HCID 24937543, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | Cyclopentanecarbonyl chloride | HCID 78284 | — |
| Reactant | 3,3-Difluorocyclobutane-1-carboxylic acid | HCID 13777789 | — |
| Reactant | HCID 68578634 | HCID 68578634 | — |
| Product | HCID 24937543 | HCID 24937543 | — |
Reaction Steps
The following were prepared analogously from [3,5-dimethyl-1-(5-trifluoromethyl-pyridin-2-yl)-1H-pyrazol-4-yl]-{5-[2-(3-phenyl-pyrrolidin-3-yl)-ethyl]-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl}-methanone using the acylating agent in parenthesis in place of cyclopentylcarbonyl chloride in the final step: III-10 (acetic anhydride) and III-12 (3,3-difluorocyclobutane-carboxylic acid using the EDCI coupling procedure in step 6 of example 6).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07625905B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-a62bc595164643e9ac9c682aeda69b35 |
| Source note | uspto-grants-2009_12 |