Ethyl isocyanate → HCID 68575347, compound

HRID 1865305Notes

Reaction equation

HRID 1865305 reaction equation
[CH3:1][C:2]1[C:7]([C:8]([N:10]2[CH2:17][CH:16]3[CH:12]([CH2:13][N:14]([CH2:18][CH2:19][CH:20]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)[CH:21]4[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]4)[CH2:15]3)[CH2:11]2)=[O:9])=[C:6]([CH3:33])[N:5]=[CH:4][N:3]=1.[N:34]([C:37](C)([CH3:39])[CH3:38])=[C:35]=[O:36].N(CC)=C=O.N(C1CCCC1)=C=O>>[CH:37]([NH:34][C:35]([N:24]1[CH2:23][CH2:22][CH:21]([CH:20]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH2:19][CH2:18][N:14]2[CH2:15][CH:16]3[CH:12]([CH2:11][N:10]([C:8]([C:7]4[C:6]([CH3:33])=[N:5][CH:4]=[N:3][C:2]=4[CH3:1])=[O:9])[CH2:17]3)[CH2:13]2)[CH2:26][CH2:25]1)=[O:36])([CH3:39])[CH3:38]

Participants

5

Reactant 4

HCID 8022Ethyl isocyanateHCID 62412tert-Butyl isocyanateHCID 643500Cyclopentyl IsocyanateHCID 68576499HCID 68576499, compound

Product 1

HCID 68575347HCID 68575347, compound

Procedure

V-2, V4 and V5 were prepared analogously from (4,6-dimethyl-pyrimidin-5-yl)-[5-(3-phenyl-3-piperidin-4-yl-propyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-methanone using 2-isocyanato-2-methyl-propane, isocyanato ethane and isocyanato cyclopentane respectively.

Sources & evidence

ORD record
ord-0aaef330dea84315909a366400523bcb
Source dataset
uspto-grants-2009_12
Patent number
US07625905B2

Reaction notes

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