HRID1865351

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(Cl)ccc1O

HCID5081913

IMD-0354

C15H8ClF6NO2

反应SMILES：CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O

HCID10981745

L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl-

C20H30N2O5

PRODUCTS

产物

反应SMILES：CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)Oc1ccc(Cl)cc1C(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1

HCID86604721

未命名化合物

收率 38.5%

PROCEDURE

实验过程

Using 5-chloro-2-hydroxy-N-[3,5-bis(trifluoromethyl)phenyl]-benzamide(compound of Example 1(1)) and N-[N-(tert-butoxycarbonyl)-L-leucyl]-L-phenylalanine as the raw materials, the same operation as the Example 24 gave the title compound.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-f35b9172169d48c4812daa151bb0fdb4
来源数据集: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US07626042B2
来源说明: uspto-grants-2009_12

反应SMILES

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:25])=[C:6]([CH:24]=1)[C:7]([NH:9][C:10]1[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[C:12]([C:20]([F:23])([F:22])[F:21])[CH:11]=1)=[O:8].[C:26]([O:30][C:31]([NH:33][C@H:34]([C:39]([NH:41][C@H:42]([C:50](O)=[O:51])[CH2:43][C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=1)=[O:40])[CH2:35][CH:36]([CH3:38])[CH3:37])=[O:32])([CH3:29])([CH3:28])[CH3:27]>>[C:26]([O:30][C:31]([NH:33][C@H:34]([C:39]([NH:41][C@H:42]([C:50]([O:25][C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:24][C:6]=1[C:7]([NH:9][C:10]1[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[C:12]([C:20]([F:21])([F:22])[F:23])[CH:11]=1)=[O:8])=[O:51])[CH2:43][C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=1)=[O:40])[CH2:35][CH:36]([CH3:38])[CH3:37])=[O:32])([CH3:27])([CH3:28])[CH3:29]