5-Bromosalicylic acid → N-[3,5-bis(trifluoromethyl)phenyl]-5-bromo-2-hydroxy-benzamide

HRID 1865353Notes

Reaction equation

HRID 1865353 reaction equation
[Br:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=O)[C:5]([OH:11])=[CH:4][CH:3]=1.[F:12][C:13]([F:26])([F:25])[C:14]1[CH:15]=[C:16]([CH:18]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:20]=1)[NH2:17]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([OH:11])=[C:6]([CH:10]=1)[C:7]([NH:17][C:16]1[CH:18]=[C:19]([C:21]([F:22])([F:23])[F:24])[CH:20]=[C:14]([C:13]([F:12])([F:25])[F:26])[CH:15]=1)=[O:9]

Participants

3

Reactant 2

HCID 69725-Bromosalicylic acidHCID 9480Benzenamine, 3,5-bis(trifluoromethyl)-

Product 1

HCID 9802636N-[3,5-bis(trifluoromethyl)phenyl]-5-bromo-2-hydroxy-benzamideYield 88.5%

Procedure

Using 5-bromosalicylic acid and 3,5-bis(trifluoromethyl)aniline as the raw materials, the same operation as the Example 1(1) gave the title compound.

Sources & evidence

ORD record
ord-d0e1cd0325234cf6a09f804b0c332ae4
Source dataset
uspto-grants-2009_12
Patent number
US07626042B2

Reaction notes

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