4-Morpholinecarbonyl chloride → 5-Bromo-2-(morpholinocarbonyl)oxy-N-[3,5-bis(trifluoromethyl)phenyl]benzamide

HRID 1865354Notes

Reaction equation

HRID 1865354 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([OH:25])=[C:6]([CH:24]=1)[C:7]([NH:9][C:10]1[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[C:12]([C:20]([F:23])([F:22])[F:21])[CH:11]=1)=[O:8].[N:26]1([C:32](Cl)=[O:33])[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:25][C:32]([N:26]2[CH2:31][CH2:30][O:29][CH2:28][CH2:27]2)=[O:33])=[C:6]([CH:24]=1)[C:7]([NH:9][C:10]1[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[C:12]([C:20]([F:21])([F:22])[F:23])[CH:11]=1)=[O:8]

Participants

3

Reactant 2

HCID 848104-Morpholinecarbonyl chlorideHCID 9802636N-[3,5-bis(trifluoromethyl)phenyl]-5-bromo-2-hydroxy-benzamide

Product 1

HCID 230703575-Bromo-2-(morpholinocarbonyl)oxy-N-[3,5-bis(trifluoromethyl)phenyl]benzamideYield 87.1%

Procedure

Using 5-bromo-2-hydroxy-N-[3,5-bis(trifluoromethyl)phenyl]benzamide and morpholine-4-carbonyl chloride as the raw materials, the same operation as the Example 71 gave the title compound.

Sources & evidence

ORD record
ord-1a90de54e21f4f8997f98469ada57362
Source dataset
uspto-grants-2009_12
Patent number
US07626042B2

Reaction notes

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