4-Morpholinecarbonyl chloride → HCID 86604724, compound

HRID 1865359Notes

Reaction equation

HRID 1865359 reaction equation
[Cl:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([NH:8][C:9]2[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[CH:12]=[C:11]([C:19]([F:22])([F:21])[F:20])[CH:10]=2)=[O:7])=[C:4]([OH:25])[CH:3]=1.[N:26]1([C:32](Cl)=[O:33])[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1>>[Cl:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([NH:8][C:9]2[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[CH:12]=[C:11]([C:19]([F:20])([F:21])[F:22])[CH:10]=2)=[O:7])=[C:4]([O:25][C:32]([N:26]2[CH2:31][CH2:30][O:29][CH2:28][CH2:27]2)=[O:33])[CH:3]=1

Participants

3

Reactant 2

HCID 848104-Morpholinecarbonyl chlorideHCID 23070355HCID 23070355, compound

Product 1

HCID 86604724HCID 86604724, compoundYield 84.1%

Procedure

Using 4-chloro-2-hydroxy-N-[3,5-bis(trifluoromethyl)phenyl]benzamide and morpholine-4-carbonyl chloride as the raw materials, the same operation as the Example 71 gave the title compound.

Sources & evidence

ORD record
ord-4ec1a3cc72ba4670acbc609b77aca982
Source dataset
uspto-grants-2009_12
Patent number
US07626042B2

Reaction notes

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