5-Iodosalicylic acid → N-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-5-iodo-benzamide

HRID 1865360Notes

Reaction equation

HRID 1865360 reaction equation
[I:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=O)[C:5]([OH:11])=[CH:4][CH:3]=1.[F:12][C:13]([F:26])([F:25])[C:14]1[CH:15]=[C:16]([CH:18]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:20]=1)[NH2:17]>>[OH:11][C:5]1[CH:4]=[CH:3][C:2]([I:1])=[CH:10][C:6]=1[C:7]([NH:17][C:16]1[CH:18]=[C:19]([C:21]([F:22])([F:23])[F:24])[CH:20]=[C:14]([C:13]([F:12])([F:25])[F:26])[CH:15]=1)=[O:9]

Participants

3

Reactant 2

HCID 83885-Iodosalicylic acidHCID 9480Benzenamine, 3,5-bis(trifluoromethyl)-

Product 1

HCID 11190699N-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-5-iodo-benzamideYield 62.2%

Procedure

Using 5-iodosalicylic acid and 3,5-bis(trifluoromethyl)aniline as the raw materials, the same operation as the Example 1(1) gave the title compound.

Sources & evidence

ORD record
ord-19529d652bf34b709beb783fd15d14b7
Source dataset
uspto-grants-2009_12
Patent number
US07626042B2

Reaction notes

Loading…