4-Morpholinecarbonyl chloride → 2-(Morpholinocarbonyl)oxy-5-phenyl-N-[3,5-bis(trifluoromethyl)phenyl]benzamide

HRID 1865362Notes

Reaction equation

HRID 1865362 reaction equation
[OH:1][C:2]1[CH:24]=[CH:23][C:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[CH:21][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:10]=[C:9]([C:17]([F:20])([F:19])[F:18])[CH:8]=1)=[O:5].[N:31]1([C:37](Cl)=[O:38])[CH2:36][CH2:35][O:34][CH2:33][CH2:32]1>>[O:34]1[CH2:35][CH2:36][N:31]([C:37]([O:1][C:2]2[CH:24]=[CH:23][C:22]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[CH:21][C:3]=2[C:4]([NH:6][C:7]2[CH:8]=[C:9]([C:17]([F:18])([F:19])[F:20])[CH:10]=[C:11]([C:13]([F:14])([F:15])[F:16])[CH:12]=2)=[O:5])=[O:38])[CH2:32][CH2:33]1

Participants

3

Reactant 2

HCID 848104-Morpholinecarbonyl chlorideHCID 117506322-Hydroxy-5-phenyl-n[3,5-bis(trifluoromethyl)phenyl]benzamide

Product 1

HCID 866047252-(Morpholinocarbonyl)oxy-5-phenyl-N-[3,5-bis(trifluoromethyl)phenyl]benzamideYield 91.4%

Procedure

Using 2-hydroxy-5-phenyl-N-[3,5-bis(trifluoromethyl)phenyl]benzamide and morpholine-4-carbonyl chloride as the raw materials, the same operation as the Example 71 gave the title compound.

Sources & evidence

ORD record
ord-eada5894589f4955a651a5022a1abc34
Source dataset
uspto-grants-2009_12
Patent number
US07626042B2

Reaction notes

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