4-Morpholinecarbonyl chloride → HCID 23070345, compound

HRID 1865366Notes

Reaction equation

HRID 1865366 reaction equation
[OH:1][C:2]1[C:3]([C:12]([NH:14][C:15]2[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[C:17]([C:25]([F:28])([F:27])[F:26])[CH:16]=2)=[O:13])=[CH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[N:29]1([C:35](Cl)=[O:36])[CH2:34][CH2:33][O:32][CH2:31][CH2:30]1>>[O:32]1[CH2:33][CH2:34][N:29]([C:35]([O:1][C:2]2[CH:11]=[CH:10][C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]=2[C:12]([NH:14][C:15]2[CH:20]=[C:19]([C:21]([F:24])([F:22])[F:23])[CH:18]=[C:17]([C:25]([F:27])([F:26])[F:28])[CH:16]=2)=[O:13])=[O:36])[CH2:30][CH2:31]1

Participants

3

Reactant 2

HCID 848104-Morpholinecarbonyl chlorideHCID 13766040HCID 13766040, compound

Product 1

HCID 23070345HCID 23070345, compoundYield 98%

Procedure

Using 3-hydroxy-N-[3,5-bis(trifluoromethyl)phenyl]-2-naphthamide and morpholine-4-carbonyl chloride as the raw materials, the same operation as the Example 71 gave the title compound.

Sources & evidence

ORD record
ord-aff0f37ae9dc431d8d153ffa96547095
Source dataset
uspto-grants-2009_12
Patent number
US07626042B2

Reaction notes

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