4-Morpholinecarbonyl chloride → HCID 69664277, compound

HRID 1865372Notes

Reaction equation

HRID 1865372 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([OH:23])=[C:6]([CH:22]=1)[C:7]([NH:9][C:10]1[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[CH:12][C:11]=1[O:20][CH3:21])=[O:8].[N:24]1([C:30](Cl)=[O:31])[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:23][C:30]([N:24]2[CH2:29][CH2:28][O:27][CH2:26][CH2:25]2)=[O:31])=[C:6]([CH:22]=1)[C:7]([NH:9][C:10]1[CH:15]=[C:14]([C:16]([F:19])([F:17])[F:18])[CH:13]=[CH:12][C:11]=1[O:20][CH3:21])=[O:8]

Participants

3

Reactant 2

HCID 848104-Morpholinecarbonyl chlorideHCID 17860173HCID 17860173, compound

Product 1

HCID 69664277HCID 69664277, compoundYield 94.9%

Procedure

Using 5-bromo-2-hydroxy-N-[2-methoxy-5-(trifluoromethyl)phenyl]benzamide and morpholine-4-carbonyl chloride as the raw materials, the same operation as the Example 71 gave the title compound.

Sources & evidence

ORD record
ord-80f100c432074eb6a7d141da2d76be24
Source dataset
uspto-grants-2009_12
Patent number
US07626042B2

Reaction notes

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