4-Morpholinecarbonyl chloride → 5-Bromo-N-[3,5-bis[(1,1-dimethyl)ethyl]phenyl}-2-[(morpholinocarbonyl)oxy]-benzamide

HRID 1865380Notes

Reaction equation

HRID 1865380 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([OH:25])=[C:6]([CH:24]=1)[C:7]([NH:9][C:10]1[CH:15]=[C:14]([C:16]([CH3:19])([CH3:18])[CH3:17])[CH:13]=[C:12]([C:20]([CH3:23])([CH3:22])[CH3:21])[CH:11]=1)=[O:8].[N:26]1([C:32](Cl)=[O:33])[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:25][C:32]([N:26]2[CH2:31][CH2:30][O:29][CH2:28][CH2:27]2)=[O:33])=[C:6]([CH:24]=1)[C:7]([NH:9][C:10]1[CH:15]=[C:14]([C:16]([CH3:17])([CH3:18])[CH3:19])[CH:13]=[C:12]([C:20]([CH3:23])([CH3:22])[CH3:21])[CH:11]=1)=[O:8]

Participants

3

Reactant 2

HCID 848104-Morpholinecarbonyl chlorideHCID 237297945-Bromo-N-[3,5-bis[(1,1-dimethyl)ethyl]phenyl)-2-hydroxybenzamide

Product 1

HCID 696649715-Bromo-N-[3,5-bis[(1,1-dimethyl)ethyl]phenyl}-2-[(morpholinocarbonyl)oxy]-benzamideYield 93.6%

Procedure

Using 5-bromo-N-{3,5-bis[(1,1-dimethyl)ethyl]phenyl}-2-hydroxybenzamide and morpholine-4-carbonyl chloride as the raw materials, the same operation as the example 71 gave the title compound.

Sources & evidence

ORD record
ord-59a3b4b161d54ad0b0817ac7169a348c
Source dataset
uspto-grants-2009_12
Patent number
US07626042B2

Reaction notes

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