5-Chlorosalicylic Acid → 5-Chloro-2-hydroxy-N-[2,5-bis(trifluoromethyl)phenyl]benzamide

HRID 1865381Notes

Reaction equation

HRID 1865381 reaction equation
[Cl:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=O)[C:5]([OH:11])=[CH:4][CH:3]=1.[F:12][C:13]([F:26])([F:25])[C:14]1[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][C:15]=1[NH2:16]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:11])=[C:6]([CH:10]=1)[C:7]([NH:16][C:15]1[CH:17]=[C:18]([C:21]([F:22])([F:23])[F:24])[CH:19]=[CH:20][C:14]=1[C:13]([F:12])([F:25])[F:26])=[O:9]

Participants

3

Reactant 2

HCID 94475-Chlorosalicylic AcidHCID 7198182,5-Bis(trifluoromethyl)aniline

Product 1

HCID 230703595-Chloro-2-hydroxy-N-[2,5-bis(trifluoromethyl)phenyl]benzamideYield 3.6%

Procedure

Using 5-chlorosalicylic acid and 2,5-bis(trifluoromethyl)aniline as the raw material, the same operation as the Example 1(1) gave the title compound.

Sources & evidence

ORD record
ord-5944ffcc31a54b249a74eb33b96d26c8
Source dataset
uspto-grants-2009_12
Patent number
US07626042B2

Reaction notes

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