4-Morpholinecarbonyl chloride → HCID 86604727, compound

HRID 1865385Notes

Reaction equation

HRID 1865385 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:26])=[C:6]([CH:25]=1)[C:7]([NH:9][C:10]1[S:11][C:12]([C:19](=[O:24])[C:20]([CH3:23])([CH3:22])[CH3:21])=[C:13]([C:15]([CH3:18])([CH3:17])[CH3:16])[N:14]=1)=[O:8].[N:27]1([C:33](Cl)=[O:34])[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:26][C:33]([N:27]2[CH2:32][CH2:31][O:30][CH2:29][CH2:28]2)=[O:34])=[C:6]([CH:25]=1)[C:7]([NH:9][C:10]1[S:11][C:12]([C:19](=[O:24])[C:20]([CH3:23])([CH3:22])[CH3:21])=[C:13]([C:15]([CH3:18])([CH3:16])[CH3:17])[N:14]=1)=[O:8]

Participants

3

Reactant 2

HCID 848104-Morpholinecarbonyl chlorideHCID 9843610HCID 9843610, compound

Product 1

HCID 86604727HCID 86604727, compoundYield 93.1%

Procedure

Using 5-chloro-N-{4-[(1,1-dimethyl)ethyl]-5-[(2,2-dimethyl)propionyl]-thiazol-2-yl}-2-hydroxybenzamide and morpholine-4-carbonyl chloride as the raw materials, the same operation as the Example 71 gave the title compound.

Sources & evidence

ORD record
ord-380d1f777e4a4ebda301d0b068fcffb6
Source dataset
uspto-grants-2009_12
Patent number
US07626042B2

Reaction notes

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