Imd-0354 → HCID 86604730, compound

HRID 1865391Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:25])=[C:6]([CH:24]=1)[C:7]([NH:9][C:10]1[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[C:12]([C:20]([F:23])([F:22])[F:21])[CH:11]=1)=[O:8].Cl[CH2:27][O:28][C:29]([N:31]1[CH2:41][CH2:40][CH:34]([C:35]([O:37][CH2:38][CH3:39])=[O:36])[CH2:33][CH2:32]1)=[O:30]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:25][CH2:27][O:28][C:29]([N:31]2[CH2:41][CH2:40][CH:34]([C:35]([O:37][CH2:38][CH3:39])=[O:36])[CH2:33][CH2:32]2)=[O:30])=[C:6]([CH:24]=1)[C:7]([NH:9][C:10]1[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[C:12]([C:20]([F:21])([F:22])[F:23])[CH:11]=1)=[O:8]

Participants

Reactant 2

HCID 5081913Imd-0354

HCID 68667057HCID 68667057, compound

Product 1

HCID 86604730HCID 86604730, compoundYield 65.7%

Procedure

Using 5-chloro-2-hydroxy-N-[3,5-bis(trifluoromethyl)phenyl]benzamide 1 sodium salt (compound of Example 43(1)) and ethyl 1-[(chloromethoxy)carbonyl]isonipecotate as the raw materials, the same operation as the Example 98 gave the title compound.

Sources & evidence

ORD record: ord-57cc61a908be46359d8e5c25d0d2037a
Source dataset: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07626042B2

Reaction notes

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