Imd-0354 → HCID 86604732, compound

HRID 1865393Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:25])=[C:6]([CH:24]=1)[C:7]([NH:9][C:10]1[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[C:12]([C:20]([F:23])([F:22])[F:21])[CH:11]=1)=[O:8].Cl[CH2:27][O:28][C:29]([N:31]([CH2:38][C:39]([O:41][CH2:42][CH3:43])=[O:40])[CH2:32][C:33]([O:35][CH2:36][CH3:37])=[O:34])=[O:30]>>[CH2:36]([O:35][C:33]([CH2:32][N:31]([CH2:38][C:39]([O:41][CH2:42][CH3:43])=[O:40])[C:29]([O:28][CH2:27][O:25][C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:24][C:6]=1[C:7]([NH:9][C:10]1[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[C:12]([C:20]([F:21])([F:22])[F:23])[CH:11]=1)=[O:8])=[O:30])=[O:34])[CH3:37]

Participants

Reactant 2

HCID 5081913Imd-0354

HCID 86604731HCID 86604731, compound

Product 1

HCID 86604732HCID 86604732, compoundYield 38.6%

Procedure

Using 5-chloro-2-hydroxy-N-[3,5-bis(trifluoromethyl)phenyl]benzamide 1 sodium salt (compound of Example 43(1)) and diethyl N-[(chloromethoxy)carbonyl]iminodiacetate as the raw materials, the same operation as the Example 98 gave the title compound.

Sources & evidence

ORD record: ord-4444704f06314ddeb175bc2316f56601
Source dataset: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07626042B2

Reaction notes

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