4-Morpholinecarbonyl chloride → HCID 86604733, compound

HRID 1865397Notes

Reaction equation

HRID 1865397 reaction equation
[Br:1][C:2]1[C:3]([OH:26])=[C:4]([CH:22]=[C:23]([Br:25])[CH:24]=1)[C:5]([NH:7][C:8]1[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:11]=[CH:10][C:9]=1[C:18]([F:21])([F:20])[F:19])=[O:6].[N:27]1([C:33](Cl)=[O:34])[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1>>[Br:1][C:2]1[C:3]([O:26][C:33]([N:27]2[CH2:32][CH2:31][O:30][CH2:29][CH2:28]2)=[O:34])=[C:4]([CH:22]=[C:23]([Br:25])[CH:24]=1)[C:5]([NH:7][C:8]1[CH:13]=[C:12]([C:14]([F:17])([F:15])[F:16])[CH:11]=[CH:10][C:9]=1[C:18]([F:19])([F:20])[F:21])=[O:6]

Participants

3

Reactant 2

HCID 848104-Morpholinecarbonyl chlorideHCID 1712525HCID 1712525, compound

Product 1

HCID 86604733HCID 86604733, compoundYield 70.6%

Procedure

Using 3,5-dibromo-2-hydroxy-N-[2,5-bis(trifluoromethyl)phenyl]benzamide and morpholine-4-carbonyl chloride as the raw materials, the same operation as the Example 71 gave the title compound.

Sources & evidence

ORD record
ord-3a1a36afc17c4b81a5c3f35951b72662
Source dataset
uspto-grants-2009_12
Patent number
US07626042B2

Reaction notes

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