Thiophene-3-boronic acid → HCID 10252154, compound

HRID 1865399Notes

Reaction equation

HRID 1865399 reaction equation
[OH:1][C:2]1[CH:24]=[CH:23][C:22](I)=[CH:21][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:10]=[C:9]([C:17]([F:20])([F:19])[F:18])[CH:8]=1)=[O:5].[S:26]1[CH:30]=[CH:29][C:28](B(O)O)=[CH:27]1>>[OH:1][C:2]1[CH:24]=[CH:23][C:22]([C:28]2[CH:29]=[CH:30][S:26][CH:27]=2)=[CH:21][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:10]=[C:9]([C:17]([F:20])([F:19])[F:18])[CH:8]=1)=[O:5]

Participants

3

Reactant 2

HCID 581760Thiophene-3-boronic acidHCID 11190699N-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-5-iodo-benzamide

Product 1

HCID 10252154HCID 10252154, compoundYield 38.7%

Procedure

Using 2-hydroxy-5-iodo-N-[3,5-bis(trifluoromethyl)phenyl]-benzamide(compound of Example 81(1)) and 3-thiopheneboronic acid as the raw materials, the same operation as the Example 81(2) gave the title compound.

Sources & evidence

ORD record
ord-608cf735531040c9bcd27839a6dc8cd3
Source dataset
uspto-grants-2009_12
Patent number
US07626042B2

Reaction notes

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