4-Morpholinecarbonyl chloride → HCID 86604734, compound

HRID 1865400Notes

Reaction equation

HRID 1865400 reaction equation
[OH:1][C:2]1[CH:24]=[CH:23][C:22]([C:25]2[CH:29]=[CH:28][S:27][CH:26]=2)=[CH:21][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:10]=[C:9]([C:17]([F:20])([F:19])[F:18])[CH:8]=1)=[O:5].[N:30]1([C:36](Cl)=[O:37])[CH2:35][CH2:34][O:33][CH2:32][CH2:31]1>>[O:33]1[CH2:34][CH2:35][N:30]([C:36]([O:1][C:2]2[CH:24]=[CH:23][C:22]([C:25]3[CH:29]=[CH:28][S:27][CH:26]=3)=[CH:21][C:3]=2[C:4]([NH:6][C:7]2[CH:12]=[C:11]([C:13]([F:15])([F:14])[F:16])[CH:10]=[C:9]([C:17]([F:18])([F:19])[F:20])[CH:8]=2)=[O:5])=[O:37])[CH2:31][CH2:32]1

Participants

3

Reactant 2

HCID 848104-Morpholinecarbonyl chlorideHCID 10252154HCID 10252154, compound

Product 1

HCID 86604734HCID 86604734, compoundYield 92.7%

Procedure

Using 2-hydroxy-5-(3-thienyl)-N-[3,5-bis(trifluoromethyl)phenyl]benzamide and morpholine-4-carbonyl chloride as the raw materials, the same operation as the Example 71 gave the title compound.

Sources & evidence

ORD record
ord-f33f84b59e9d4b56bd9de6eb8314f680
Source dataset
uspto-grants-2009_12
Patent number
US07626042B2

Reaction notes

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